Rats anesthetized with pentobarbital and ventilated artificially were intoxicated with 1
mg/kg X min propranolol i.v. After 30 min heart rate, mean arterial blood pressure
and peripheral resistance had dropped by about 50% and cardiac output by about 25%
and were stable for up to 120 min. Isoprenaline proved to be the best antidote for the
treatment of propranolol intoxication antagonizing the bradycardia by 76% and the
hypotension completely.
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