Question: Name: 3 The Figure That Follows Shows The Pedigree Of A Family In Which A Completely Penetrant, Autosomal Dominant Disease Is Transmitted Through Three Generations. Each Member Of The Family Was Genotyped At A Biallelic SNP Locus (the Alleles Are C And A) And The Microarray Analysis Is Presented Below The Pedigree 11 5 III 12 5 6 7 8 9 10 Microarray …
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Name: 3 The figure that follows shows the pedigree of a family in which a completely penetrant, autosomal dominant disease is transmitted through three generations. Each member of the family was genotyped at a biallelic SNP locus (the alleles are C and A) and the microarray analysis is presented below the pedigree 11 5 III 12 5 6 7 8 9 10 Microarray data at SNP generation individual 1 2 1 2 4 5 6 1 2 3 4 5 6 7 8 9 10 11 12 с a What matings are informative? (3 pt) b. What is the relative map distance between the disease locus and the SNP? (2 pt) c Calculate the lod score for this pedigree. Is this enough information to conclude that the disease locus is linked with the SNP locus? (2 pts) d You analyze a pedigree from a different family with the same disease and SNP alleies and find 12 parentals and 1 recombinant Calculate the Lod score for this pedigree. Do you now have sufficient data to conclude linkage between the disease and SNP loci? (3 pts)
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