Question: In Humans, Approximately 70% Of Lidocaine In The Bloodstream Is Bound To Plasma Proteins When The Drug Is Within The Normal Therapeutic Concentration Range (1-3 Micrograms Per Ml). Lidocaine And Certain Other Drugs Bind To A Class Of Plasma Proteins Called Alpha-1-acid Glycoproteins. Studies Have Demonstrated That Levels Of Alpha-1-acid Glycoprotein …
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In humans, approximately 70% of lidocaine in the bloodstream is bound to plasma proteins when the drug is within the normal therapeutic concentration range (1-3 micrograms per ml). Lidocaine and certain other drugs bind to a class of plasma proteins called alpha-1-acid glycoproteins. Studies have demonstrated that levels of alpha-1-acid glycoprotein are elevated up to three-fold following an acute myocardial infarction a) What change would be expected in the protein-bound fraction of lidocaine in myocardial infarction patients relative to normal (non-MI) patients? Please explain. Would you expect any difference between total drug levels in these two groups? Please explain. Also give three assumptions that determine your answers
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