Question: Genomic Imprinting: Remember That The 15q Region Contains The UBE3A Gene, Which Is Imprinted Paternally, And The SNPRN Gene, Which Is Imprinted Maternally. How Many Functional UBE3A Alleles And How Many Functional SNPRN Alleles Does A Healthy Child Express? How Many Functional UBE3A Alleles And How Many Functional SNPRN Does A Child Express Who Inherited …

Genomic imprinting: Remember that the 15q regioncontains the UBE3A gene, which is imprinted paternally, and theSNPRN gene, which is imprinted maternally.

1. How many functional UBE3A alleles and how manyfunctional SNPRN alleles does a healthy child express?

2. How many functional UBE3A alleles and how manyfunctional SNPRN does a child express who inherited a paternalchromosome 15 with 15q13 deleted?

3. How many functional UBE3A alleles and how manyfunctional SNPRN does a child express who inherited a maternalchromosome 15 with 15q13 deleted?

Explain why deletion of the 15q13 region on chromosome15 inherited from the mother will lead to Angelman syndrome, whilethe same deleted region inherited from the father will lead toPrader-Willi syndrome.