Question: A. The Following Table Reports Pharmacokinetic Data For The Drug Cefazolin. BIOAVAILABILITY (ORAL) (%) URINARY EXCRETION BOUND IN PLASMA CLEARANCE (minVIVOL DIST(LAN) HALF-LIFE (%) (hours) Cefazolin 90+10 892 0.95 +0.17 0.100.00 22 +002 RD, Ees RD 7D TRD Prepancy TP Home Reported. Following A Single 1 G IV (model-fted Color IM Dose To Healthy Adultes …

A. The following table reports pharmacokinetic data for the drug Cefazolin. BIOAVAILABILITY (ORAL) (%) URINARY EXCRETION BOUND IN PLASMA CLEARANCE (minVIVOL DIST(LAN) HALF-LIFE (%) (hours) Cefazolin 90+10 892 0.95 +0.17 0.100.00 22 +002 RD, Ees RD 7D TRD Prepancy TP Home reported. Following a single 1 g IV (model-fted Color IM dose to healthy adultes Reference: Schuid W. et al. Moustactem and cateczalin: comparative pharmacokinetics in normal subjects Actimicrobe Agents Chemother. 1081.70.013-010 a. Given the information about changes in clearance and volume of distribution in pregnancy, and renal disease (RD), predict the corresponding changes in volume of distribution and half-life in the same populations. Renal Disease Pregnancy Volume of Distribution 1 + 1 Elimination Half-lite T T > Write the equations you used to make your decision: b. Calculate total body clearance for a normal adult (70 kg) in ml/min and L/hr: c. Calculate renal clearance for a normal adult (70 kg) in mL/min and L/hr: d. Calculate renal filtration clearance for cefazolin (assume normal adult)