Question: A Hypothetical Genetic Disease Causes The Body To Produce Antibodies That Compete With Acetylcholine For Receptors On The Motor End Plate. Patients With This Disease Exhibit Varying Degrees Of Muscle Weakness In The Affected Muscles. If You Could Administer A Drug That Inhibits Acetylcholinesterase Or A Drug That Blocks Acetylcholine, Which One Would …
- A hypothetical genetic disease causes the body to produceantibodies that compete with acetylcholine for receptors on themotor end plate. Patients with this disease exhibit varying degreesof muscle weakness in the affected muscles. If you could administera drug that inhibits acetylcholinesterase or a drug that blocksacetylcholine, which one would you use to alleviate thesesymptoms?
- This is a case of competition between acetylcholine receptorsand the antibody.
- To make the patient’s acetylcholine more effective, a drug thatinhibits acetylcholinesterase would slow the breakdown ofacetylcholine, relieving some of the weakness.
- An acetylcholine blocker would be greater than doingnothing.
- Prescribe an antibody that reduces the risk of muscleweakness.
- Prescribe an antibody that reduces the risk ofinflammation.
- Thirty minutes after Mary completed her 20 mile race, shebegins to notice severe muscle soreness and stiffness in he legs.Her urine is dark colored. She wonders whether she may have damagedher muscles during the race. She visits the ER, and the doctororders several blood tests. What kind of blood tests can helpdetermine whether muscle damage has occurred?
- If muscle damage occurred, the doctor would find enzymes suchas creatine kinase and proteins such as myoglobin or troponin inthe bloodstream released by injured skeletal muscle cells.
- The level of the substances in “A” above correlates with theseverity of the injury.
- A liver enzymes test should be ordered.
- A cardiac enzymes test should be ordered.
- A and B
- What ion is needed to enter the cell to trigger an actionpotential?
- Potassium
- Calcium
- Chloride
- Sodium
- Phosphate
- Many visceral smooth muscle cells lack motor neuroninnervation. How are their contractions coordinated andcontrolled?
- Gap junctions interconnect visceral smooth muscle fibers.
- An action potential that begins in one will spread to itssurrounding neighbors.
- The action potential can be triggered by stretching, hormones,chemical changes, or stimulation at a myoneural junction on adistant smooth muscle cell.
- Smooth muscle cells have intercalated discs which facilitatethe action potential being propagated.
- A, B, and C
- Megan wants to enter a weight lifting competition and consultsyou as to what type of muscle fibers she needs to develop and howshe should go about it. What would you suggest to her?
- Weight lifting requires aerobic endurance.
- Megan would want to develop her fast fibers for short termmaximum strength.
- She would achieve “B” above by engaging in activities thatinvolve frequent, brief, but intensive workouts, such as heavyweights to the point of muscle fatigue.
- The fatigue triggers the production of new myofilamentproteins, leading to muscle bulk and strength.
- B, C, and D.
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