Question: 12. TSH: (a) Regulates The Synthesis Of T4 And T3 (5) Binds Receptors On Thyroid Coloidal Cells (c) Production Is Feedback Regulated By Circulating T3 Bound To TBPA (d) Is A Tripeptide (e) Levels Peak Around Midday And At Its Nadir At Midnight, 13. The Following Will Result In Increased Binding Of Thyroid Hormone : (a) Decreased Transthyretin Levels …

12. TSH: (a) Regulates the synthesis of T4 and T3 (5) Binds receptors on thyroid coloidal cells (c) Production is feedback regulated by circulating T3 bound to TBPA (d) is a tripeptide (e) Levels peak around midday and at its nadir at midnight, 13. The following will result in increased binding of Thyroid Hormone : (a) Decreased transthyretin levels (b) Familial dysalbuminemia hyperthyroxinemia (c) Nephrosis (d) Presence of T4 autoantibodies (e) Treatment with phenytoin 14. In Grave’s disease : (a) Antibodies to thyroid hormones inactivates T3 and T4 (b) Pituitary TSH secretion is supressed (c) There is proptosis due to thickening of retro-orbital muscle (d) Diagnosis is made from finding low plasma levels of TH with high levels of TSH (e) There is a possibility of relapse after treatment 15. The following paired hormones have the same ß sub unit: (a) TSH/FSH (b) LH/HCG (c) FSH/LH (d) TSH/LH (e) hCG/LH 16. In pituitary development: (a) Pit-1 determines cell specific expression of GH,PRL,TSH (b) Development of corticotrope cells requires the T-pit (c) Pit-1 determines expression of GH in lactotropes (d) Mutations in transcription factors causes defects such as pituitary dysplasia (e) Development of corticotrope cells does not requires the T-pit 17. The diabetogenic effect of human growth hormone involves all the following conditions : (a) Excess of growth hormone secretion (b) Raised blood glucose levels (c) Continual pancreatic release of insulin (d) Beta-cell autoimmune damage (e) Eventual inactivity of insulin